Ability of osteoclast formation from peripheral monocytes using anti-fusion regulatory protein-1/cd98/4f2 monoclonal antibodies in patients with osteoporosis
✍ Scribed by Masatoshi Tajima; Yasumitsu Higuchi; Noriki Miyamoto; Shigeomi Higuchi; Morihiro Ito; Masato Tsurudome; Akihiro Sudo; Yasuhiko Ito; Atsumasa Uchida
- Book ID
- 102393660
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 415 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0736-0266
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✦ Synopsis
Abstract
We investigated the difference in osteoclast formation between patients with osteoporosis and two healthy control groups by inducing it from peripheral blood monocytes with use of anti‐fusion regulatory protein‐1 monoclonal antibody. The group of patients with osteoporosis consisted of 35 women and excluded secondary osteoporosis, and the control groups consisted of 12 young healthy volunteers (control I) or 10 individuals age‐matched to the patients with osteoporosis (control II). Osteoclast formation declined with age between the two control groups, but this decline was not significant. Fusion rate and the mean number of nuclei in osteoclasts were significantly less in the patients with osteoporosis than in the young or agematched controls. It was clearly demonstrated that the ability of monocytes to fuse declines significantly in patients with osteoporosis.