Abietane Diterpenoids from the Roots of some Mexican Salvia Species (Labiatae): Chemical Diversity, Phytogeographical Significance, and Cytotoxic Activity
✍ Scribed by Baldomero Esquivel; Ana Adela Sánchez; Fredd Vergara; Wilber Matus; Simón Hernandez-Ortega; M. Teresa Ramírez-Apan
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 218 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1612-1872
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✦ Synopsis
From the roots of some Mexican Salvia species, classified in subgenus Jungia, several diterpenoids belonging to abietane (i.e., 3 ± 7), salvifolane (9 3 20,10 3 6)-diabeoabietane) (i.e., 2), and totarane (i.e., 10) carbocyclic skeletons were isolated together with two 20-nor-and one 6,7-secoabietane derivatives, 1 and 9, and 8, respectively. While compounds 2 ± 10 were previously known from different sources, compound 1 is a new 20norabietane derivative, whose structure was deduced by spectroscopic means and confirmed by X-raydiffraction analysis. The phytogeographical significance of the distribution of 20-norabietanic diterpenoids in the genus suggested an evolutionary link between the Chinese and New-World Salvias. Compounds 2 and 8 were tested for cell-growth inhibition activity against several human cancer cell lines and human normal lymphocytes, while 2 showed a moderate cytotoxic activity, 8 exhibited a moderate yet selective activity against leukemia cell line.