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ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma

✍ Scribed by Ushmorov, A; Leithäuser, F; Ritz, O; Barth, T F E; Möller, P; Wirth, T


Book ID
109886812
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
194 KB
Volume
22
Category
Article
ISSN
0887-6924

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Loss of expression of ZAC/PLAGL1 in diff
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## Abstract __ZAC/PLAGL1__ is a ubiquitously expressed, imprinted tumor suppressor gene located on 6q24, a chromosomal region that is frequently deleted in diffuse large B‐cell lymphoma (DLBCL). Like p53, ZAC regulates cell cycle arrest and apoptosis concomitantly, and loss of expression is implica