Aberrations of the Chk2 tumour suppressor in advanced urinary bladder cancer
✍ Scribed by Bartkova, Jirina; Guldberg, Per; Grønbæk, Kirsten; Koed, Karen; Primdahl, Hanne; Møller, Klaus; Lukas, Jiri; Ørntoft, Torben F; Bartek, Jiri
- Book ID
- 110068945
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 267 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
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## Abstract The p16^Ink4^/MTSI/CDKN2 is a cell‐cycle regulatory inhibitor of cyclin‐dependent kinase 4 (cdk4), and a candidate tumour suppressor whose gene on chromosome band 9p21 is frequently deleted or mutated in diverse types of cancer. Cdk4 in association with its D‐type cyclin partners, toget