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Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer

✍ Scribed by Naushad Shaik Mohammad; Rupasree Yedluri; Pavani Addepalli; Suryanarayana Raju Gottumukkala; Raghunadha Rao Digumarti; Vijay Kumar Kutala


Book ID
106459390
Publisher
Springer
Year
2010
Tongue
English
Weight
337 KB
Volume
349
Category
Article
ISSN
0300-8177

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Aminoflavone induces oxidative DNA damag
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## Abstract Aminoflavone (5‐amino‐2‐(4‐amino‐3‐fluorophenyl)‐6,8‐difluoro‐7‐methylchromen‐4‐one; AF; NSC 686288), a novel anticancer candidate agent, is undergoing clinical evaluation. AF induces DNA‐protein cross‐links (DPCs), γ‐H2AX phosphorylation, aryl hydrocarbon receptor (AhR) signaling, apop