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Aberrant processing of mutant amyloid precursor protein (APP) leads to altered morphology in cultured cells

✍ Scribed by Chen, Li-Min; Chen, Yen-Chun; Hsiao, Hui-Pin; Chen, Bai-Hsiun; Chao, Mei-Chyn

Book ID
124124157
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
195 KB
Volume
15
Category
Article
ISSN
0197-4580

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## Abstract The amyloid precursor protein (APP) is cleaved enzymatically by nonamyloidogenic and amyloidogenic pathways. α‐Secretase (α‐secretase), cleaves APP within the β‐amyloid (AΞ²) sequence, resulting in the release of a secreted fragment of APP (Ξ±APPs) and precluding AΞ² generation. In this st