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Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

โœ Scribed by Ting, D. T.; Lipson, D.; Paul, S.; Brannigan, B. W.; Akhavanfard, S.; Coffman, E. J.; Contino, G.; Deshpande, V.; Iafrate, A. J.; Letovsky, S.; Rivera, M. N.; Bardeesy, N.; Maheswaran, S.; Haber, D. A.

Book ID
120345233
Publisher
American Association for the Advancement of Science
Year
2011
Tongue
English
Weight
880 KB
Volume
331
Category
Article
ISSN
0036-8075

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Frequent frameshift mutations of simple nucleotide repeats in the protein-encoding regions, as well as replication errors (RERs) at microsatellite loci, have recently been demonstrated in gastrointestinal tumors. These genetic instabilities have been considered indicative of an increased risk of acc