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Aberrant Overexpression of Pyruvate Kinase M2 Is Associated With Aggressive Tumor Features and the BRAF Mutation in Papillary Thyroid Cancer

✍ Scribed by Feng, Chen; Gao, Yun; Wang, Cuifang; Yu, Xiaohui; Zhang, Wei; Guan, Haixia; Shan, Zhongyan; Teng, Weiping

Book ID
120809501
Publisher
Endocrine Society
Year
2013
Tongue
English
Weight
358 KB
Volume
98
Category
Article
ISSN
0021-972X

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## Abstract The role of aberrant tumor suppressor gene methylation in the aggressiveness of papillary thyroid cancer (PTC) has not been documented. By showing promoter methylation‐induced gene silencing in PTC‐derived cell lines, we first demonstrated the functional consequence of methylation of se