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Aberrant Neurofilament Phosphorylation in Alzheimer Disease

✍ Scribed by Nancy H. Sternberger, Ludwig A. Sternberger and Jürg Ulrich

Book ID: 123632097
Publisher: National Academy of Sciences
Year: 1985
Tongue: English
Weight: 868 KB
Volume: 82
Category: Article
ISSN: 0027-8424
DOI: 10.2307/26076

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## Abstract The c‐Jun N‐terminal kinase (JNK) pathway is known to be activated by oxidative stress and can lead to either defensive‐protective adaptations in the cell or apoptosis. The JNK pathway is activated in Alzheimer disease (AD), as demonstrated in studies showing higher levels of phospho‐JN