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Aberrant Methylation of the Netrin-1 Receptor GenesUNC5CandDCCDetected in Advanced Colorectal Cancer

✍ Scribed by Kenji Hibi; Hiroki Mizukami; Atsushi Shirahata; Tetsuhiro Goto; Makiko Sakata; Yutaka Sanada


Book ID
105980575
Publisher
Springer
Year
2009
Tongue
English
Weight
263 KB
Volume
33
Category
Article
ISSN
0364-2313

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## Abstract Colorectal cancer arises from the progressive accumulation of mutations and epigenetic alterations in colon epithelial cells. Such alterations often deregulate signaling pathways that affect the formation of colon cancer, such as the Wnt, RAS‐MAPK and TGF‐β pathways. The tumor promoting