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Aberrant gene promoter methylation marking disease progression in multiple myeloma

✍ Scribed by Chim, C-S; Liang, R; Leung, M-H; Yip, S-F; Kwong, Y-L

Book ID: 110056724
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 112 KB
Volume: 20
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2404205

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## Abstract ## BACKGROUND. Methylation‐mediated suppression of detoxification, DNA repair, and tumor suppressor genes has been implicated in cancer development and progression. Studies also have indicated that concordant methylation of multiple genes (methylator phenotypes), rather than a single g