## Abstract Accumulating evidence implicates epigenetic changes such as hypermethylation in carcinogenesis. We investigated whether DNA methylation of 5 tumor suppressor genes in pleural fluid samples could aid in diagnosis of malignant effusion. In samples from 47 patients with malignant pleural e
Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma
β Scribed by Masanori Fujii; Nobukazu Fujimoto; Akio Hiraki; Kenichi Gemba; Keisuke Aoe; Shigeki Umemura; Hideki Katayama; Nagio Takigawa; Katsuyuki Kiura; Mitsune Tanimoto; Takumi Kishimoto
- Book ID
- 114703155
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 301 KB
- Volume
- 103
- Category
- Article
- ISSN
- 1347-9032
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## Abstract ## BACKGROUND. Promising results with trimodality therapy combining surgery, chemotherapy, and radiotherapy have been obtained in the management of patients with malignant pleural mesothelioma (MPM). However, the histologic subtype has to be taken into account because of its influence