Aberrant crypt foci and colon tumors in F344 rats have similar increases in proliferative activity

S-adenosyl L-methionine inhibits azoxyme

S-adenosyl L-methionine inhibits azoxymethane-induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco-2 cell growth in 3D culture

✍ Suresh Guruswamy; Malisetty V. Swamy; Chang-In Choi; Vernon E. Steele; Chinthala 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 237 KB 👁 1 views

## Abstract __S__‐Adenosyl L‐methionine (SAM) is a universal methyl group donor to various intermediary metabolites, hormones, proteins, neurotransmitters, phospholipids and nucleic acids. Deficiency of folate, which plays a role in the synthesis of SAM leads to increased risk for colon cancer. Thi