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Aberrant CpG island methylation in cancer cell lines arises in the primary cancers from which they were derived

โœ Scribed by Walter, Kimberly M; Skinner, Halcyon; Jaffee, Elizabeth; Hruban, Ralph H; Goggins, Michael; Ueki, Takashi


Book ID
110066482
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
150 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract Aberrant methylation of CpG islands is a common alteration in human colon cancer. Methylation of only a limited number of loci has been studied in aberrant crypt foci (ACF), the earliest identified premalignant lesions in the colon, and in only a limited number of lesions from the same