𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Aberrant CD2 expression in precursor-B acute lymphoblastic leukemia of childhood

✍ Scribed by Dunphy, Cherie H.; Chu, Jen-Yih

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
221 KB
Volume
52
Category
Article
ISSN
0361-8609

No coin nor oath required. For personal study only.

✦ Synopsis

Aberrant CD2 expression in childhood precursor-B ALL is rare and has recently been reported with an incidence of 3.6% in a study by Cantu-Rajnoldi et al. [Haematologica 77:384, 19921. There was no association of the CD2 co-expression with other known prognostic factors. Our study represents the second one in the literature. Out of 60 childhood acute lymphoblastic leukemias, analyzed morphologically and by flow cytometric immunophenotyping, 49 were of precursor B origin. Of these 49 cases, CD2 coexpression was detected in 2, yielding an incidence of 4.1%. The complete immunophenotypic profiles of these two cases were as follows, respectively: (1) CD19+, CD20-, CD24+, CD10+, slg-, CD2+, CD3-, CD5-, CD7-, CD13-, CD33-, CD34+, Tdt+; and (2) CD19+, Cytogenetic analysis revealed a normal male chromosome pattern in case 1 and an abnormal female chromosome pattern [4 cells: 46, XX, del (6q) (q21 q23) and 9 cells: 46, XX, del ( l l q ) (q14 q23)] in case 2. Both patients were in continuous complete remission at last follow-up.

πŸ“œ SIMILAR VOLUMES

Induction failure in acute lymphoblastic
Induction failure in acute lymphoblastic leukemia of childhood
✍ Lewis B. Silverman; Richard D. Gelber; Mary L. Young; Virginia Kimball Dalton; R πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 114 KB πŸ‘ 2 views

## BACKGROUND. Although it is widely accepted that failure to achieve complete remission (CR) portends a poor prognosis in childhood acute lymphoblastic leukemia (ALL), there is variability in the precise definition of induction failure and, to the authors' knowledge, few published data exist regar

Cerebral glucose metabolism in survivors
Cerebral glucose metabolism in survivors of childhood acute lymphoblastic leukemia
✍ Meri KΓ€hkΓΆnen; Liisa MetsΓ€honkala; Heikki Minn; Tapio Utriainen; Tapio Korhonen; πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 96 KB πŸ‘ 2 views

## BACKGROUND. Cranial radiation therapy (CRT) has been suggested to be a principal factor responsible for long term neurocognitive deficits in survivors of acute lymphoblastic leukemia (ALL). However, neither reduction of the irradiation dose nor the elimination of irradiation entirely appear to h

Thrombocytosis as a presenting feature o
Thrombocytosis as a presenting feature of acute lymphoblastic leukemia in childhood
✍ Julie Blatt; Lila Penchansky; Marianna Horn πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 349 KB πŸ‘ 2 views

To determine the incidence of thrombocytosis at presentation in acute lymphoblastic leukemia (ALL), medical records of all children diagnosed at the Children's Hospital of Pittsburgh from 1980 to 1987 were reviewed. Out of 217 such patients, 7 (3.2%) had platelet counts greater than 400,000/mm3. All

Abdominal ultrasound findings during and
Abdominal ultrasound findings during and after treatment of childhood acute lymphoblastic leukemia
✍ Ojala, Airi E.; Lanning, F. Peter; Lanning, B. Marjatta πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 171 KB πŸ‘ 1 views

Background. The treatment of acute leukemia in childhood has been increasingly successful. Concurrently, severe leukemia-related gastrointestinal complications have become more common. Methods. We evaluated the findings of the abdominal ultrasound (US) examinations of 52 children with acute lymphob