Aberrant cAMP Metabolism in NF1 Malignant Peripheral Nerve Sheath Tumor Cells
โ Scribed by Ian Dang; George H. De Vries
- Book ID
- 106484732
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 405 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0364-3190
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๐ SIMILAR VOLUMES
Neurofibromatosis type 1 (NF1) patients have 10% of lifetime risk for developing malignant peripheral nerve sheath tumors (MPNST), one of the most aggressive cancers. We examined the spectrum of constitutional NF1 mutations among 24 NF1 patients with MPNST. We found mutations in 18 patients: four me
## Communicated by Riccardo Fodde About 10% of neurofibromatosis type 1 (NF1) patients develop malignant peripheral nerve sheath tumors (MPNSTs) and represent considerable patient morbidity and mortality. Elucidation of the genetic mechanisms by which inherited and acquired NF1 disease gene variant