The discovery and synthesis of highly po
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Renee Aspiotis; Denis Deschênes; Daniel Dubé; Yves Girard; Zheng Huang; France L
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Article
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2010
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Elsevier Science
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English
⚖ 344 KB
The SAR study of a series of 6-aryloxymethyl-8-aryl substituted quinolines is described. Optimization of the series led to the discovery of compound 26b, a highly potent (IC50=0.6 nM) and selective PDE4D inhibitor with a 75-fold selectivity over the A, B, and C subtypes and over 18,000-fold selectiv