ABCC11 expression is regulated by estrogen in MCF7 cells, correlated with estrogen receptor expression in postmenopausal breast tumors and overexpressed in tamoxifen-resistant breast cancer cells
β Scribed by Lidereau, R.; Kruh, G. D; Dumontet, C.; Cohen, P.; Payen, L.; Honorat, M.; Mesnier, A.; Vendrell, J.; Guitton, J.; Bieche, I.
- Book ID
- 115315960
- Publisher
- Bioscientifica
- Year
- 2008
- Tongue
- English
- Weight
- 337 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1351-0088
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The cyclinβdependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30β60βmin independent of new protein synthesis in the estrogen recept
Data from immunocytochemical assessment of estrogen receptor (ER) regulation in MCF-7 cells under estrogenic and anti-estrogenic stimulation were compared with those obtained by enzyme immunoassay (Abbott ER-EIA). Similar trends were observed, although ER level variations were less marked when asses