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ABCB1 Haplotypes Differentially Affect the Pharmacokinetics of the Acid and Lactone Forms of Simvastatin and Atorvastatin

โœ Scribed by Keskitalo, JE; Kurkinen, KJ; Neuvonen, PJ; Niemi, M


Book ID
109845585
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
190 KB
Volume
84
Category
Article
ISSN
0009-9236

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A method for simultaneous quantitation of both the acid and lactone forms of atorvastatin, a new synthetic inhibitor of HMG-CoA reductase that is being marketed for the treatment of high serum cholesterol, and both the acid and lactone forms of its two biotransformation products, 2-hydroxyatorvastat