Drug transport in intestine, liver and kidney is similar, because in each case transport occurs across a barrier of epithelial cells. However, the physiological conditions differ in each organ: intestinal drug absorption is largely influenced by physicochemical conditions in the intestinal lumen; ac
ABC transporters in liver, kidney, and intestine
β Scribed by Stanton, Bruce
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 51 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0085-2538
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The central role of the vitamin D endocrine system in calcium homeostasis is now well established [DeLuca and Schnoes, 1983; Kumar, 19841. Research during the early part of this century demonstrated the critical role of the fat-soluble vitamin, vitamin D, in preventing rickets [Mellanby, 1919; McCol
ATP-binding cassette (ABC) transporters are able to efflux their substrate drugs from the cells. We compared expression of efflux proteins in normal human corneal epithelial tissue, primary human corneal epithelial cells (HCEpiC), and corneal epithelial cell culture model (HCE model) based on human
ATP-binding cassette (ABC) transporters are members of a protein superfamily which can be responsible for efflux of drugs from cells of target organisms. In this way, the transporters may provide a mechanism of protection against cytotoxic drugs. In laboratory-generated mutants of fungi, overproduct