AB-polymer Networks with Cooligoester and Poly(n-butyl acrylate) Segments as a Multifunctional Matrix for Controlled Drug Release
✍ Scribed by Christian Wischke; Axel T. Neffe; Susi Steuer; Eva Engelhardt; Andreas Lendlein
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 338 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
Semi‐crystalline AB‐copolymer networks from oligo[(ε‐caprolactone)‐co‐glycolide]dimethacrylates and n‐butylacrylate have recently been shown to exhibit a shape‐memory functionality, which may be used for self‐deploying and anchoring of implants. In this study, a family of such materials differing in their molar glycolide contents χ~G~ was investigated to determine structure–property functional relationships of unloaded and drug loaded specimens. Drug loading and release were evaluated, as well as their degradation behavior in vitro and in vivo. Higher χ~G~ resulted in higher loading levels by swelling and a faster release of ethacridine lactate, lower melting temperature of polymer crystallites, and a decrease in shape fixity ratio of the programmed temporary shape. For unloaded networks, the material behavior in vivo was independent of the mechanical load associated with different implantation sites and agreed well with data from in vitro degradation studies. Thus, AB networks could be used as novel matrices for biofunctional implants, e.g., for urogenital applications, which can self‐anchor in vivo and provide mechanical support, release drugs, and finally degrade in the body to excretable fragments.
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