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Ab initio simulations of Cu binding sites on the N-terminal region of prion protein

✍ Scribed by Sara Furlan; Giovanni La Penna; Francesco Guerrieri; Silvia Morante; Gian Carlo Rossi

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 498 KB
Volume: 12
Category: Article
ISSN: 1432-1327
DOI: 10.1007/s00775-007-0218-x

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## Abstract Transmissible spongiform encephalopathies are a group of neurodegenerative disorders caused by a posttranslational, conformational change in the cellular isoform of the prion protein (PrP^C^) into an infectious, disease‐associated form (PrP^Sc^). Increasing evidence supports a role for