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Ab initio investigations on the local anesthetics procaine, lidocaine and heptacaine

✍ Scribed by M. Remko; P.Th. Van Duijnen


Book ID
119115854
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
592 KB
Volume
105
Category
Article
ISSN
0166-1280

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Theoretical studies on local anesthetics
✍ Joaquim Delphino Da Motta Neto; Ricardo Bicca De Alencastro πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 556 KB

The molecular basis of the pharmacological action of tertiary amine local anesthetics LA is still unclear. However, there is experimental evidence that the LA penetrates into the axon as a neutral form and acts in the charged form from the intracellular phase. In this work we report quantum chemical