Theoretical studies on local anesthetics
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Joaquim Delphino Da Motta Neto; Ricardo Bicca De Alencastro
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Article
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1997
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John Wiley and Sons
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English
β 556 KB
The molecular basis of the pharmacological action of tertiary amine local anesthetics LA is still unclear. However, there is experimental evidence that the LA penetrates into the axon as a neutral form and acts in the charged form from the intracellular phase. In this work we report quantum chemical