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Ab initio hybrid quantum mechanical/molecular mechanical studies of the mechanisms of the enzymes protein kinase and thymidine phosphorylase

✍ Scribed by D.W Sheppard; N.A Burton; I.H Hillier


Book ID
114140988
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
196 KB
Volume
506
Category
Article
ISSN
0166-1280

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Computational studies of the domain move
✍ Steven W. Rick; Yuri G. Abashkin; Richard L. Hilderbrandt; Stanley K. Burt πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 400 KB πŸ‘ 2 views

Thymidine phosphorylase (TP) is a dual substrate enzyme with two domains. Each domain binds a substrate. In the crystal structure of Escherichia coli TP, the two domains are arranged so that the two substrate binding sites are too far away for the two substrates to directly react. Molecular dynamics