## Abstract We have theoretically examined the relative binding affinities (RBA) of typical ligands, 17β‐estradiol (EST), 17α‐estradiol (ESTA), genistein (GEN), raloxifene (RAL), 4‐hydroxytamoxifen (OHT), tamoxifen (TAM), clomifene (CLO), 4‐hydroxyclomifene (OHC), diethylstilbestrol (DES), bispheno
Ab initio fragment molecular orbital study of ligand binding to human progesterone receptor ligand-binding domain
✍ Scribed by Takanori Harada; Kenji Yamagishi; Tatsuya Nakano; Kazuo Kitaura; Hiroaki Tokiwa
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 209 KB
- Volume
- 377
- Category
- Article
- ISSN
- 0028-1298
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
An analytical method is described whereby progesterone is isolated from pregnancy plasma on the basis of the high affinity and specificity of the progesterone receptor for its ligand. Partially purified progesterone receptor ligand-binding domain, expressed as a protein A fusion protein in Escherich
## Abstract The CH/π hydrogen bond is a weak molecular force occurring between CH groups (soft acids) and π‐systems (soft bases), and has been recognized to be important in the interaction of proteins with their specific ligands. For instance, it is well known that Src homology‐2 protein (SH2) reco
Based on our previous result of the three-dimensional model of the µ-opioid receptor, binding conformations of 13 fentanyl analogs and three-dimensional structures for the complexs of these analogs with µ-opioid receptor were constructed employing the molecular modeling method and our binding confor