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AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression

✍ Scribed by Mohr, A; Henderson, G; Dudus, L; Herr, I; Kuerschner, T; Debatin, K-M; Weiher, H; Fisher, K J; Zwacka, R M


Book ID
110039449
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
333 KB
Volume
11
Category
Article
ISSN
0969-7128

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AAV-encoded expression of TRAIL in exper
✍ Mohr, A; Henderson, G; Dudus, L; Herr, I; Kuerschner, T; Debatin, K-M; Weiher, H πŸ“‚ Article πŸ“… 2004 πŸ› Nature Publishing Group 🌐 English βš– 333 KB

Gene transfer vectors based on the adeno-associated virus (AAV) are used for various experimental and clinical therapeutic approaches. In the present study, we demonstrate the utility of rAAV as a tumoricidal agent in human colorectal cancer. We constructed an rAAV vector that expresses tumor necros