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A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner

โœ Scribed by Lorna C Hamilton; Ivana Vojnovic; Timothy D Warner

Book ID
110004455
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
245 KB
Volume
127
Category
Article
ISSN
0007-1188

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โœ David P.G. Hamon; Peter J. Hayball; Ralph A. Massy-Westropp; Josephine L. Newton ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 450 KB

The four stereoisomers of the parent keto acid of the oximino drug ximoprofen have been prepared in high enantiomeric purity. The stereochemistry in the propionic acid chain was established by the combination of Sharpless epoxidation followed by stereoselective hydrogenolysis of the benzylic carbon-