A40 Bone morphogenetic protein and WNT signaling pathways are critical in joint cartilage homeostasis in vivo

Bone Morphogenetic Protein signaling in

Bone Morphogenetic Protein signaling in joint homeostasis and disease

✍ Rik J.U. Lories; Frank P. Luyten 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 429 KB

Bone morphogenetic protein and transform

Bone morphogenetic protein and transforming growth factor β inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1β

✍ Martina Kaiser; Jochen Haag; Stephan Söder; Brigitte Bau; Thomas Aigner 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 284 KB 👁 1 views

## Abstract ## Objective Bone morphogenetic protein (BMP) and transforming growth factor β (TGFβ) are potent anabolic factors in adult articular chondrocytes. In this study, we investigated whether intracellular inhibitors of BMP and TGFβ signaling, inhibitory Smad6 (I‐Smad6) and I‐Smad7, are expr