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A39 LPS induced catabolic effect on articular cartilage is dependent on the presence of toll-like receptor-4 and is antagonized by osteogenic protein-1

Book ID
114348987
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
250 KB
Volume
13
Category
Article
ISSN
1063-4584

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✍ K. Bobacz; I. G. Sunk; J. G. Hofstaetter; L. Amoyo; C. D. Toma; S. Akira; T. Wei 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 586 KB

## Abstract ## Objective To assess the presence of Toll‐like receptors (TLRs) 1–9 in human articular cartilage, and to investigate the effects of lipopolysaccharide (LPS)–induced activation of TLR‐4 on biosynthetic activity and matrix production by human articular chondrocytes. ## Methods TLRs 1