A2HS*11: A new allele of alpha-2-HS-glycoprotein found in Afro-Caribbeans

✍ Scribed by Dr. Sara A. Westwood; Philip J. Seaman; Peter J. Ablett; Isao Yuasa; Sebastian Weidinger; Kazuo Umetsu

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 308 KB
• Volume: 8
• Category: Article
• ISSN: 0173-0835
• DOI: 10.1002/elps.1150081205

✦ Synopsis

A 2 HS*Il in Afro. Caribbeans

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T-cells decreased to one-half of the initial value, while 2.4-2.5 pg/108 sialic acid cells was released into the medium. The EPM histogram changed with the treatment, from two to one peak for whole spleen cells, and from one to two peaks for T-cells. On calculation of the surface charge from EPM, onehalf of the negative surface charge, which determines EPM, was found to be due to sialic acid. However, the sialic acid released by the enzyme corresponded to more than the total negative surface charge. This may reflect a difference in the distribution of the sialic acid in the cell surface. The sialic acid exposed on the outer membrane (10 A) was found to be the main component responsible for the negative surface charge in mouse T-cells.