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A23 Abnormal expression of cartilage-degrading enzymes in human osteoarthritic chondrocytes is associated with DNA de-methylation of specific promoter CpGs


Book ID
114348971
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
133 KB
Volume
13
Category
Article
ISSN
1063-4584

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Association between the abnormal express
✍ Helmtrud I. Roach; Norikazu Yamada; Kelvin S. C. Cheung; Simon Tilley; Nicholas πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 423 KB πŸ‘ 1 views

## Abstract ## Objective To investigate whether the abnormal expression of matrix metalloproteinases (MMPs) 3, 9, and 13 and ADAMTS‐4 by human osteoarthritic (OA) chondrocytes is associated with epigenetic β€œunsilencing.” ## Methods Cartilage was obtained from the femoral heads of 16 patients wit