The activity of purified interleukin 2 (IL2), obtained by the recombinant DNA technology, on the proliferative response of human B cells stimulated with low concentrations of anti-p antibody was investigated. Recombinant IL 2 was capable of augmenting the proliferative response of anti-p-activated B
A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies
✍ Scribed by Nadine Hövelmeyer; Sonja Reissig; Nguyen Thi Xuan; Petra Adams-Quack; Dominika Lukas; Alexei Nikolaev; Dirk Schlüter; Ari Waisman
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 390 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0014-2980
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## Abstract CD22‐deficient mice are characterized by B cell hyperactivity and autoimmunity. We have constructed knock‐in CD22^–/–^ mice, expressing an anti‐DNA heavy (H) chain (D42), alone or combined with Vκ1‐Jκ1 or Vκ8‐Jκ5 light (L) chains. The Ig‐targeted mice produced a lupus‐like serology that
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