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A015 In situ therapy can induce regeneration of cochlear hair cells in vivo

✍ Scribed by C. La Croix; E. Mornet; T. Montier; G. Valette; G. Potard; Y. Gauvin; R. Marianowski


Book ID
117339105
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
39 KB
Volume
75
Category
Article
ISSN
0165-5876

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## Abstract We constructed a powerful artificial cytoprotective protein, FNK, from an antiapoptotic member of the BCL‐2 family, Bcl‐x~L~. To test the efficacy of FNK in protecting cochlear hair cells (HCs) from aminoglycoside‐induced cell death in vivo, we fused FNK with protein transduction domain