A β-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D

Alzheimer's disease and hereditary cereb

Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis–dutch type share a decrease in cerebrospinal fluid levels of amyloid β-protein precursor

✍ Dr. William E. van Nostrand; Steven L. Wagner; Joost Haan; Egbert Bakker; Raymun 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB 👁 1 views

## Abstract The amyloid β‐protein is a 39‐42 amino acid peptide that is deposited in senile plaques and in cerebral vessel walls in individuals with Alzheimer's disease, Down's syndrome, hereditary cerebral hemorrhage with amyloidosis–Dutch type (HCHW A‐D), and, to a much lesser extent, normal agin