A Zinc(II)/Poly(γ-glutamic acid) Complex as an Oral Therapeutic for the Treatment of Type-2 Diabetic KKAy Mice

✍ Scribed by Subarna Karmaker; Tapan K. Saha; Yutaka Yoshikawa; Hiromu Sakurai

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 322 KB
• Volume: 9
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200800190

✦ Synopsis

Abstract

In developing new insulin‐mimetic zinc(II) complexes with various ligands including a biodegradable polymer, we prepared and characterized a Zn(γ‐pga) complex in solution as well as in solid, and investigated its in vitro insulin‐mimetic activity and in vivo antidiabetic effect in type‐2 diabetic KKA^y^ mice. The in vitro insulin‐mimetic activity of the Zn(γ‐pga) complex was considerable better than that of ZnSO~4~. The Zn(γ‐pga) complex normalized the hyperglycemia in KKA^y^ mice within 21 d when administrated orally at doses of 10–20 mg (0.15–0.31 mmol) Zn per kg body mass for 30 d. In addition, the impaired glucose tolerance, elevated HbA~1c~ levels and metabolic syndromes were significantly improved in Zn(γ‐pga)‐treated KKA^y^ mice relative to those administrated with saline and ZnSO~4~.

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