✦ LIBER ✦
A word of caution: 1,4,5,6-tetrahydronicotinamide adenine dinucleotide (phosphate) should be used with care in acidic and neutral media
✍ Scribed by G. Branlant; B. Eiler; J.F. Biellmann
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 390 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0003-2697
No coin nor oath required. For personal study only.
✦ Synopsis
The decomposition of 1,4,5,6-tetrahydronicotinamide adenine dinucleotide (phosphate) (5,6-THN)AD(P) under neutral and acidic conditions is catalyzed by general acid. Adenosine Sdiphosphoribose (ADPR) has been isolated in high yield by high-performance liquid chromatography from decomposition of (5,6-THN)AD in phosphate buffer, pH 6.8. The limitation of conditions under which (5,6-THN)AD(P) should be used as an analog of NAD(P)H are emphasized.