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A ‘waterproof’ catalyst for the oxidation of secondary amines to nitrones with alkyl hydroperoxides

✍ Scribed by Massimiliano Forcato; William A. Nugent; Giulia Licini

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
136 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Catalytic oxidation of secondary amines to nitrones using alkyl hydroperoxides as primary oxidant has been demonstrated for the first time. The titanium alkoxide catalyst is protected from co-product water by the combined use of a tightly binding trialkanolamine ligand and molecular sieves. Nitrones can be obtained in high yield (up to 98%) under homogeneous, anhydrous conditions and even in the absence of solvent. The reactions are fast (2-7 h) and good selectivity can be achieved with as little as 1% catalyst.

📜 SIMILAR VOLUMES

C3-Symmetric Titanium(IV) Triphenolate A
C3-Symmetric Titanium(IV) Triphenolate Amino Complexes for a Fast and Effective Oxidation of Secondary Amines to Nitrones with Hydrogen Peroxide
✍ Cristiano Zonta; Elisa Cazzola; Miriam Mba; Giulia Licini 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB 👁 2 views

## Abstract The efficient catalytic oxidation of secondary amines to nitrones using hydrogen peroxide as primary oxidant is described. The titanium(IV) complex **2** bearing a __C__~3~‐symmetrical triphenolate amino ligand has proved to be an air‐ and water‐tolerant complex that efficiently catalyz