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A voltage-clamp study of the effects of colchicine on the squid giant axon

โœ Scribed by D. C. Chang

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
843 KB
Volume
115
Category
Article
ISSN
0021-9541

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โœฆ Synopsis

The effects of colchicine applied inside a squid giant axon were studied using voltage-clamp and internal perfusion techniques. It was found that colchicine selectively and reversibly suppresses the sodium conductance during excitation. The possible involvement of the microtubular structure in the functioning of the excitable channel is discussed.

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