A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: A future drug against a fatal neoplastic disease?

✍ Scribed by Marco Tomasetti; Nina Gellert; Antonio Procopio; Jiri Neuzil

• Book ID: 102272121
• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: French
• Weight: 63 KB
• Volume: 109
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.20062

✦ Synopsis

Abstract

Malignant mesothelioma is a fatal type of neoplasia of the pleura and the peritoneum with currently no known cure. Therefore, discovery of an efficient antimesothelioma drug with low deleterious side effects is desirable. Here, we studied in vivo the effect of α‐tocopheryl succinate, a semisynthetic vitamin E analogue with proapoptotic and anticancer activity and selectivity for malignant cells, on experimental peritoneal mesothelioma using immunocompromised mice. Compared to untreated animals, the agent increased their survival >3‐fold. Our finding warrants further testing of vitamin E analogues as potential antimesothelioma drugs. © 2004 Wiley‐Liss, Inc.