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A vindesine-anti-CEA conjugate cytotoxic for human cancer cells in vitro

✍ Scribed by Johnson, J R; Ford, C H; Newman, C E; Woodhouse, C S; Rowland, G F; Simmonds, R G

Book ID
109835228
Publisher
Nature Publishing Group
Year
1981
Tongue
English
Weight
493 KB
Volume
44
Category
Article
ISSN
0007-0920

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Drug localisation and growth inhibition
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✍ G. F. Rowland; R. G. Simmonds; V. A. Gore; C. H. Marsden; W. Smith πŸ“‚ Article πŸ“… 1986 πŸ› Springer-Verlag 🌐 English βš– 560 KB

The distribution of tritiated vindesine (3H-VDS) was studied in the tissues and tumours of athymic mice bearing a human colorectal tumour xenograft. Selective tumour localisation was obtained when 3H-VDS was injected as a conjugate with a monoclonal anti-CEA antibody (11.285.14) but not as a conjuga