A very efficient preparation of 1,2-diketones

✍ Scribed by M.C. Carre; P. Caubere

• Book ID: 104228781
• Publisher: Elsevier Science
• Year: 1985
• Tongue: French
• Weight: 190 KB
• Volume: 26
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)98629-5

✦ Synopsis

Summahy : 1teaAmen.t 04 a-AiomethtrLktstnneci with CL&.+CuO in aqueous actione addoh& do_ cowrtienaondin_a J,Z-o!icutbonqL compouvd. We have previously shown1 that condensation of benzyne on 1,2-diketone monoketal enolates led to the formation of benzocyclobutenols in good to excellent yields. These compounds are of potential interest in the synthesis of polycyclic derivatives2 as well as in medicinal chemistry. 3 Large scale preparation of these alcohols are only limited by the large scale obtention of 1,2-diketone monoketals. The simplest way in obtaining these starting substrates