𝔖 Bobbio Scriptorium
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A versatile, synthesis of β-amino acids using the Nicholas reaction. I. Application to β-lactams of the carbapenem class

✍ Scribed by Peter A. Jacobi; Wanjun Zheng


Book ID
108379999
Publisher
Elsevier Science
Year
1993
Tongue
French
Weight
334 KB
Volume
34
Category
Article
ISSN
0040-4039

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## Abstract Deprotonation of __N__‐protected esters of the amino acids alanine 1, ethylglycin 6, valine 7, and phenylalanine 8 with LDA and subsequent addition of various metal salts result in the formation of a probably chelated metal enolate. Aldol reactions of these enolates with aldehydes affor