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A versatile synthesis of the 1,4-dihydroxynaphthoquinone nucleus

✍ Scribed by Ileana Menegazzo; Giancarlo Sandonà; Stefano Moro; V Sheeba; Giuseppe Zagotto


Book ID
104210661
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
146 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis


The electrochemical oxidation of dierent methoxynaphthalenes to aord the corresponding 5,8-dihydroxy-1,4-naphthoquinones has been examined. This method constitutes a new alternative and ecient route for the synthesis of the 5,8-dihydroxy-1,4-naphthoquinone nucleus.


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## Abstract The reaction of 1‐(2‐aminophenyl)pyrrole with aromatic or heteroaromatic aldehydes in ethanol and catalytic amounts of acetic acid leads to 4,5‐dihydropyrrolo[1,2‐__a__]quinoxalines in high yields. When aliphatic aldehydes were used under the same conditions, a slow oxidation to the cor