A versatile synthesis of peptidyl fluoromethyl ketones
β Scribed by Barbara Imperiali; Robert H. Abeles
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 222 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Academy of Sciences, ti-Fluoromethyl ketones are formed via the reaction of allene epoxides with tetrabutylammonium fluoride trihydrate (TBAF-3H20) in THF. The syntheses of fluorine-containing analogues of some biologically active ketones have attracted considerable attention. owing to their activit
Peptide fluoromethyl ketones have been synthesized for the first time. The inhibitor 3-(Nbenzyloxycarbonylphenylalanylamido)-DL-l-fluoro-2-butanone (Z-Phe-AlaCHZF) was found to be a 30-fold more potent inactivator of human cathepsin B than 3-(N-benzyloxycarbonylphenylalanylamido)~L-I-diazo-2-butanon