A variant of lactate dehydrogenase in somatic tissues of pigeons: Physicochemical properties and genetic control
✍ Scribed by Zinkham, William H. ;Kupchyk, Luba ;Blanco, Antonio ;Isensee, Harriet
- Publisher
- John Wiley and Sons
- Year
- 1966
- Tongue
- English
- Weight
- 777 KB
- Volume
- 162
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
Three genetic loci ( a , b, and c ) control lactate dehydrogenase synthesis in many mammalian and avian species. A survey of the lactate dehydrogenase isozyme composition of somatic tissues from approximately 1,000 wild pigeons revealed three phenotypic classes. The frequency distribution of the three classes in wild pigeons and the results of appropriate breeding experiments demonstrated that the phenotypic differences were due to alleles at the b-locus. One of the alleles produces a B' polypeptide with an electrophoretic mobility identical to that of the A polypeptide, but with substrate affinitv and heat inactivation properties similar to those of the B polypeptide.