Analogues of oxytocin antagonists bearin
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George Flouret; Olivier Chaloin; Lenka Borovickova; Jirina SlaninovΓ
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Article
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2006
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John Wiley and Sons
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English
β 141 KB
Substitution of the side chain carboxamido group at position 4 in the potent oxytocin antagonist (OTA) [ThiaPmp(1), D-Trp(2), Cys(6), Arg(8)]-OT, PA, in which ThiaPmp = beta,beta-(3-thiapentamethylene)-beta-mercaptopropionic acid, led to [Orn(Car)(4)]-PA, ([Cit(4)]-PA), which had uterotonic antagoni