A two-step practical synthesis of dehydroalanine derivatives
✍ Scribed by Karell Pérez-Labrada; Edwin Flórez-López; Evelyn Paz-Morales; Luis D. Miranda; Daniel G. Rivera
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 621 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A novel solid-phase synthetic method for dehydroalanines and dehydropeptides has been developed. Elimination of the sulfone part with concomitant release from the solid support afforded the desired dehydroalanine derivatives. The products were given in good yields and excellent purities.
A novel synthesis of N1 alkyl-substituted pyrazoles with a free amino group at the C4 position is described. Commercially available 4nitropyrazole was found to readily undergo Mitsunobu reactions with primary and secondary alcohols. Subsequent reduction of the nitro group via hydrogenation affords 1