✦ LIBER ✦

A Two-Stage Test for Distinguishing Random, Pseudo-Random and Nonrandom Mating Populations

✍ Scribed by Dr. J. J. Tai; Joumiao Liu

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 426 KB
Volume: 38
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.4710380611

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

There is no such an implication that a population in Hardy‐Weinberg equilibrium must have undergone random mating. Therefore, it is unequivocal that the usual tests for “Hardy‐Weinberg equilibrium” are indeed tests for “random union of gametes” but not for “random mating”. In this paper, utilizing population characteristics expressed in equilibrium state (equilibrium or disequilibrium) and mating behavior (random or nonrandom), a two‐stage testing procedure for distinguishing random, pseudo‐random and nonrandom mating populations is proposed. At the first stage, a population is tested for Hardy‐Weinberg equilibrium. If insignificant result (i.e., in equilibrium) is obtained, then to a second stage the population is further tested for mating behavior. Random mating‐pairs data are needed here for analysis instead of random individuals for usual Hardy‐Weinberg equilibrium tests. Since distinguishing the three types of mating populations depends on the combined results of two stages, the probability of correct determination of the two‐stage tests is discussed by simulation studies.

📜 SIMILAR VOLUMES

Comparative studies of serologic tests f

Comparative studies of serologic tests for rheumatoid disease. I. A comparison of a latex test and two erythrocyte agglutination tests in a random population sample

✍ J. Ball; R. De Graaff; H. A. Valkenburg; F. Westendorp Boerma 📂 Article 📅 1962 🏛 John Wiley and Sons 🌐 English ⚖ 276 KB 👁 2 views

## Abstract Sera from a random sample of the population of Rotterdam were tested by a latex fixation test (LFT) in Leiden, a sensitized sheep cell agglutination test (SCAT) in Manchester and a human erythrocyte test (HEAT) in Groningen with an overall agreement of 93.3 per cent. In both rheumatoid

Estimators for the parameters of a multi

Estimators for the parameters of a multivariate normal random vector with incomplete data on two subvectors and test of independence

✍ Serge B. Provost 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 514 KB

Pilot studies of 2 and 1 course carbopla

Pilot studies of 2 and 1 course carboplatin as adjuvant for stage I seminoma: Should it be tested in a randomized trial against radiotherapy?

✍ R.T.D. Oliver; P.M. Edmonds; J.Y.H. Ong; M.J. Ostrowski; A.W. Jackson; H. Baille 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 645 KB

Asymptotic Expansion of the Misclassific

Asymptotic Expansion of the Misclassification Probabilities of D- and A-Criteria for Discrimination from Two High Dimensional Populations Using the Theory of Large Dimensional Random Matrices

✍ H. Saranadasa 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 546 KB

Individual patient data meta-analysis of

Individual patient data meta-analysis of time-to-event outcomes: one-stage versus two-stage approaches for estimating the hazard ratio under a random effects model

✍ Jack Bowden; Jayne F Tierney; Mark Simmonds; Andrew J Copas; Julian PT Higgins 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 657 KB

POBASCAM, a population-based randomized

POBASCAM, a population-based randomized controlled trial for implementation of high-risk HPV testing in cervical screening: Design, methods and baseline data of 44,102 women

✍ Nicole W.J. Bulkmans; Lawrence Rozendaal; Peter J.F. Snijders; Feja J. Voorhorst 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 253 KB 👁 2 views

## Abstract Cytological cervical screening is rather inefficient because of relatively high proportions of false negative and false positive smears. To evaluate the efficiency of high‐risk human papillomavirus (hrHPV) testing, by GP5+/6+ PCR‐enzyme immunoassay (EIA), in conjunction with cytology (I