A two-point volume localized T1 measurement sequence for in vivo spectroscopy using a surface coil

✍ Scribed by N. M. Yongbi; M. O. Leach; G. S. Payne; D. J. Collins

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 414 KB
• Volume: 5
• Category: Article
• ISSN: 0952-3480
• DOI: 10.1002/nbm.1940050208

✦ Synopsis

Abstract

A technique for obtaining T~1~ values from well localized regions using surface coils and with a clinically practicable measurement time is described. The method uses a two‐point Inversion‐Recovery/Saturation‐Recovery (IR/SR) sequence in conjunction with the image‐selected in vivo spectroscopy localization scheme. T~1~ values are obtained by comparing the ratio of peak areas with those in a pre‐computed look‐up table. The method was tested by measuring the T~1~s of six calibrated water phantoms doped with different concentrations of gadolinium. This indicated an accuracy of 3% for T~1~ values in the range 400‐1500 ms. ^31^P spectra and T~1~ values of P~i~, phosphocreatine and α‐, β‐ and γ‐NTP metabolites from the calf muscle of healthy volunteers were obtained with the sequence employing B~i~‐insensitive excitation pulses and a surface coil. The T~1~ values fall within the range of published values obtained by other techniques.