A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas

Inactivation of the von Hippel–Lindau (V

Inactivation of the von Hippel–Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis

✍ Steven C. Clifford; Amanda H. Prowse; Nabeel A. Affara; Charles H. C. M. Buys; E 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 2 views

Inactivation of tumour suppressor gene(s) (TSGs) on 3p appears to be a critical event in the pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity (LOH) in sporadic RCC samples has implicated roles for TSGs in three specific regions of 3p in RCC development: (1